Lack of Mucosal Cholinergic Innervation Is Associated With Increased Risk of Enterocolitis in Hirschsprung’s DiseaseSummary

Lack of Mucosal Cholinergic Innervation Is Associated With Increased Risk of Enterocolitis in Hirschsprung’s DiseaseSummary

Background & Aims: Hirschsprung’s disease (HSCR) is a congenital intestinal motility disorder defined by the absence of enteric neuronal cells (ganglia) in the distal gut. The development of HSCR-associated enterocolitis remains a life-threatening complication. Absence of enteric ganglia imp...

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Bibliographic Details
Main Authors: Simone Keck, Virginie Galati-Fournier, Urs Kym, Michèle Moesch, Jakob Usemann, Isabelle Müller, Ulrike Subotic, Sasha J. Tharakan, Thomas Krebs, Eleuthere Stathopoulos, Peter Schmittenbecher, Dietmar Cholewa, Philipp Romero, Bertram Reingruber, Elisabeth Bruder, NIG Study Group, Stefan Holland-Cunz
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Enterocolitis
Neuroimmunology
Cholinergic Nerve Fibers
Macrophages
Th17 Cells
Microbiome
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21000564

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http://www.sciencedirect.com/science/article/pii/S2352345X21000564

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