Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks

Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor-β (TGF-β), Sonic Hedgehog (SHH), and WNT pathways. These signaling pathways crosstalk to each other and...

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Bibliographic Details
Main Authors: Jingyu Zhang, Xiao-Jun Tian, Jianhua Xing
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Journal of Clinical Medicine
Subjects:
EMT
SHH
WNT
Online Access:http://www.mdpi.com/2077-0383/5/4/41