A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) cells meet the higher energy, metabolic, and signaling demands of the cell by increasing mitochondrial biogenesis and mitochondrial protein translation. Blocking mitochondrial protein synthesis through genetic and chemical approaches kills human AML cells at all...

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Bibliographic Details
Main Authors: Gregory A. Reed, Gary J. Schiller, Suman Kambhampati, Martin S. Tallman, Dan Douer, Mark D. Minden, Karen W. Yee, Vikas Gupta, Joseph Brandwein, Yulia Jitkova, Marcela Gronda, Rose Hurren, Aisha Shamas‐Din, Andre C. Schuh, Aaron D. Schimmer
Format: Article
Language:English
Published: Wiley 2016-11-01
Series:Cancer Medicine
Subjects:
Cox‐1
Cox‐4
mitochondrial protein synthesis
pharmacodynamics
pharmacokinetics
Online Access:https://doi.org/10.1002/cam4.845

Internet

https://doi.org/10.1002/cam4.845

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