Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals

Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals

Translational readthrough gives rise to low abundance proteins with C-terminal extensions beyond the stop codon. To identify functional translational readthrough, we estimated the readthrough propensity (RTP) of all stop codon contexts of the human genome by a new regression model in silico, identif...

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Bibliographic Details
Main Authors: Fabian Schueren, Thomas Lingner, Rosemol George, Julia Hofhuis, Corinna Dickel, Jutta Gärtner, Sven Thoms
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-09-01
Series:eLife
Subjects:
translational readthrough
stop codon suppression
lactate dehydrogenase
gene regulation
genome-wide in silico screen
peroxisomal targeting signal
Online Access:https://elifesciences.org/articles/03640

Internet

https://elifesciences.org/articles/03640

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