DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells

Abstract Nitric Oxide (NO) is an endogenous pulmonary vasodilator produced by endothelial NO synthase (eNOS). Asymmetric dimethyl L‐arginine (ADMA) is an endogenous inhibitor of eNOS activity. In endothelial cells, ADMA is hydrolyzed to L‐citrulline primarily by dimethylarginine dimethyl‐aminohydrol...

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Bibliographic Details
Main Authors: Jennifer K. Trittmann, Hanadi Almazroue, Yi Jin, Leif D. Nelin
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.14150