Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype

Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype

Abstract Background Transposable elements (TEs) make up > 50% of the human genome, and the majority of retrotransposon insertions are truncated and many are located in introns. However, the effects of retrotransposition on the host genes remain incompletely known. Results We report here that inse...

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Bibliographic Details
Main Authors: Zhuqing Wang, Hayden McSwiggin, Simon J. Newkirk, Yue Wang, Daniel Oliver, Chong Tang, Sandy Lee, Shawn Wang, Shuiqiao Yuan, Huili Zheng, Ping Ye, Wenfeng An, Wei Yan
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Mobile DNA
Subjects:
Retrotransposon
CRISPR/Cas9
LINE-1
IAP
MaLR
Alternative splicing
Online Access:http://link.springer.com/article/10.1186/s13100-019-0162-7

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http://link.springer.com/article/10.1186/s13100-019-0162-7

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