Mutations in the β-Tubulin Gene TUBB5 Cause Microcephaly with Structural Brain Abnormalities
The formation of the mammalian cortex requires the generation, migration, and differentiation of neurons. The vital role that the microtubule cytoskeleton plays in these cellular processes is reflected by the discovery that mutations in various tubulin isotypes cause different neurodevelopmental di...
Main Authors: | Martin Breuss, Julian Ik-Tsen Heng, Karine Poirier, Guoling Tian, Xavier Hubert Jaglin, Zhengdong Qu, Andreas Braun, Thomas Gstrein, Linh Ngo, Matilda Haas, Nadia Bahi-Buisson, Marie-Laure Moutard, Sandrine Passemard, Alain Verloes, Pierre Gressens, Yunli Xie, Kathryn J.H. Robson, Deepa Selvi Rani, Kumarasamy Thangaraj, Tim Clausen, Jamel Chelly, Nicholas Justin Cowan, David Anthony Keays |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2012-12-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124712004147 |
Similar Items
-
Endoplasmic reticulum and Golgi stress in microcephaly
by: Sandrine Passemard, et al.
Published: (2019-10-01) -
Prevalence of βIII-tubulin (TUBB3) expression in human normal tissues and cancers
by: Fermín Person, et al.
Published: (2017-10-01) -
Preparation of Immobilized Recombinant Tubulin Beta(TuBb) on Chitosan Nanoparticles by Covalent Binding Method
by: Yan Qingfang, et al.
Published: (2016-01-01) -
A Complex Cortical Malformation Caused by a Mutation in the Tubulin-Encoding TUBB3 Gene
by: Yu Hyun Lee, et al.
Published: (2020-09-01) -
Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma
by: Lan Jiang, et al.
Published: (2020-09-01)