Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation

Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation

Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation...

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Bibliographic Details
Main Authors: Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Wenzhao Wang, Fuhang Song, Huanqin Dai, Jingyu Zhang, Ronald J. Quinn, Tanja Grkovi, Houwei Luo, Lixin Zhang, Xueting Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2016-09-01
Series:Synthetic and Systems Biotechnology
Subjects:
Biotransformation
Glycosylation
Tanshinone IIA
Mucor rouxianus
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X15300223

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http://www.sciencedirect.com/science/article/pii/S2405805X15300223

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