Activation of Human NK Cells by Bordetella pertussis Requires Inflammasome Activation in Macrophages

Activation of Human NK Cells by Bordetella pertussis Requires Inflammasome Activation in Macrophages

Pertussis is a highly contagious respiratory infection caused by the bacterium Bordetella pertussis. Humans are the only known natural reservoir of B. pertussis. In mice, macrophages and NK cells have a key role in confining B. pertussis to the respiratory tract. However, the mechanisms underlying t...

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Bibliographic Details
Main Authors: Michiel M. Kroes, Rob Mariman, Daniëlle Hijdra, Hendrik-Jan Hamstra, Karlijn J. W. M. van Boxtel, Jos P. M. van Putten, Jelle de Wit, Elena Pinelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
inflammasome
NLRP3
crosstalk
interferon-gamma
interleukin-18
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02030/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02030/full

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