A model-based approach to identify binding sites in CLIP-Seq data.

Cross-linking immunoprecipitation coupled with high-throughput sequencing (CLIP-Seq) has made it possible to identify the targeting sites of RNA-binding proteins in various cell culture systems and tissue types on a genome-wide scale. Here we present a novel model-based approach (MiClip) to identify...

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Bibliographic Details
Main Authors: Tao Wang, Beibei Chen, MinSoo Kim, Yang Xie, Guanghua Xiao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3979666?pdf=render