Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability

Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability

Abstract Background Mesenchymal stem cells (MSCs) are attracting increasing interest for cell-based therapies, making use of both their immuno-modulating and regenerative potential. For such therapeutic applications, a massive in vitro expansion of donor cells is usually necessary to furnish suffici...

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Bibliographic Details
Main Authors: Daniela Hladik, Ines Höfig, Ursula Oestreicher, Johannes Beckers, Martina Matjanovski, Xuanwen Bao, Harry Scherthan, Michael J. Atkinson, Michael Rosemann
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Stem Cell Research & Therapy
Subjects:
Ionizing radiation
Adult stem cells
Mesenchymal stem cells
Genetic instability
DNA repair
Micronuclei
Online Access:http://link.springer.com/article/10.1186/s13287-019-1334-6

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http://link.springer.com/article/10.1186/s13287-019-1334-6

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