Win, Lose, or Tie: Mathematical Modeling of Ligand Competition at the Cell–Extracellular Matrix Interface

Win, Lose, or Tie: Mathematical Modeling of Ligand Competition at the Cell–Extracellular Matrix Interface

Integrin transmembrane proteins conduct mechanotransduction at the cell–extracellular matrix (ECM) interface. This process is central to cellular homeostasis and therefore is particularly important when designing instructive biomaterials and organoid culture systems. Previous studies suggest that fi...

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Bibliographic Details
Main Authors: Zeynep Karagöz, Thomas Geuens, Vanessa L. S. LaPointe, Martijn van Griensven, Aurélie Carlier
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
integrin
ligand competition
computational model
extracellular matrix
ordinary differential equation
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.657244/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.657244/full

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