Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.

Bibliographic Details
Main Authors: Jack A. Bibby, Harriet A. Purvis, Thomas Hayday, Anita Chandra, Klaus Okkenhaug, Sofia Rosenzweig, Ivona Aksentijevich, Michael Wood, Helen J. Lachmann, Claudia Kemper, Andrew P. Cope, Esperanza Perucha
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17179-4

Internet

https://doi.org/10.1038/s41467-020-17179-4

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