Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease

Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the huntingtin (htt) gene, which results in an aberrant form of the protein (mhtt). This leads to motor and cognitive deficits associated with corticostriatal and hippocampal alteratio...

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Bibliographic Details
Main Authors: Marta García-Forn, Sara Martínez-Torres, Gerardo García-Díaz Barriga, Jordi Alberch, Montse Milà, Garikoitz Azkona, Esther Pérez-Navarro
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Neurobiology of Disease
Subjects:
Cognitive function
DARPP-32
Hippocampus
Motor coordination
Mutant huntingtin aggregates
phosphoERK1/2
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118305175

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http://www.sciencedirect.com/science/article/pii/S0969996118305175

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