Nuclear microenvironments modulate transcription from low-affinity enhancers

Nuclear microenvironments modulate transcription from low-affinity enhancers

Transcription factors bind low-affinity DNA sequences for only short durations. It is not clear how brief, low-affinity interactions can drive efficient transcription. Here, we report that the transcription factor Ultrabithorax (Ubx) utilizes low-affinity binding sites in the Drosophila melanogaster...

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Bibliographic Details
Main Authors: Albert Tsai, Anand K Muthusamy, Mariana RP Alves, Luke D Lavis, Robert H Singer, David L Stern, Justin Crocker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
transcription factors
Hox genes
transcriptional enhancers
super resolution
live imaging
Online Access:https://elifesciences.org/articles/28975

Internet

https://elifesciences.org/articles/28975

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