Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells

Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells

The production of nitric oxide (NO) is required for early stage embryo implantation into the uterus. Here the authors show that during differentiation of naive mouse ESCs, early production of endogenous NO leads to a mesendoderm differentiation commitment pathway by inhibiting the action of the tran...

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Bibliographic Details
Main Authors: Chiara Cencioni, Francesco Spallotta, Matteo Savoia, Carsten Kuenne, Stefan Guenther, Agnese Re, Susanne Wingert, Maike Rehage, Duran Sürün, Mauro Siragusa, Jacob G. Smith, Frank Schnütgen, Harald von Melchner, Michael A. Rieger, Fabio Martelli, Antonella Riccio, Ingrid Fleming, Thomas Braun, Andreas M. Zeiher, Antonella Farsetti, Carlo Gaetano
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03668-0

Internet

https://doi.org/10.1038/s41467-018-03668-0

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