Repeated dermal application of the common preservative methylisothiazolinone triggers local inflammation, T cell influx, and prolonged mast cell-dependent tactile sensitivity in mice.

Repeated dermal application of the common preservative methylisothiazolinone triggers local inflammation, T cell influx, and prolonged mast cell-dependent tactile sensitivity in mice.

Occupational exposure to toxic chemicals increases the risk of developing localized provoked vulvodynia-a prevalent, yet poorly understood, chronic condition characterized by sensitivity to touch and pressure, and accumulation of mast cells in painful tissues. Here, we topically sensitized female ND...

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Bibliographic Details
Main Authors: Jaclyn M Kline, Erica Arriaga-Gomez, Tenzin Yangdon, Beebie Boo, Jasmine Landry, Marietta Saldías-Montivero, Nefeli Neamonitaki, Hanna Mengistu, Sayira Silverio, Hayley Zacheis, Dogukan Pasha, Tijana Martinov, Brian T Fife, Devavani Chatterjea
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0241218

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https://doi.org/10.1371/journal.pone.0241218

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