Characterization of NS5A and NS5B Resistance-Associated Substitutions from Genotype 1 Hepatitis C Virus Infected Patients in a Portuguese Cohort

Characterization of NS5A and NS5B Resistance-Associated Substitutions from Genotype 1 Hepatitis C Virus Infected Patients in a Portuguese Cohort

This study is focused on the prevalent NS5 coding region resistance-associated substitutions (RASs) in DAA-naive genotype (GT)1 HCV-infected patients and their potential impact on success rates. Plasma RNA from 81 GT1 HCV-infected patients was extracted prior to an in-house nested RT-PCR of the NS5...

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Bibliographic Details
Main Authors: Ruben Brandão, Rute Marcelino, Fátima Gonçalves, Isabel Diogo, Ana Carvalho, Joaquim Cabanas, Inês Costa, Pedro Brogueira, Fernando Ventura, Ana Miranda, Kamal Mansinho, Perpétua Gomes
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Viruses
Subjects:
hepatitis C virus
direct-acting antivirals
resistance-associated substitutions
NS5A
NS5B
Online Access:http://www.mdpi.com/1999-4915/10/5/223

Internet

http://www.mdpi.com/1999-4915/10/5/223

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