The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis.

The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis.

Enzymatic inactivation of Rho-family GTPases by the glucosyltransferase domain of Clostridioides difficile Toxin B (TcdB) gives rise to various pathogenic effects in cells that are classically thought to be responsible for the disease symptoms associated with C. difficile infection (CDI). Recent in...

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Bibliographic Details
Main Authors: Terry W Bilverstone, Megan Garland, Rory J Cave, Michelle L Kelly, Martina Tholen, Donna M Bouley, Philip Kaye, Nigel P Minton, Matthew Bogyo, Sarah A Kuehne, Roman A Melnyk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008852

Internet

https://doi.org/10.1371/journal.ppat.1008852

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