Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

Non-invasive imaging and quantification of human beta cell mass remains a major challenge. We performed pre-clinical in vivo validation of a peptide previously discovered by our group, namely, P88 that targets a beta cell specific biomarker, FXYD2γa. We conjugated P88 with DOTA and then co...

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Bibliographic Details
Main Authors: Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Narayana Murthy Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio L. Eizirik
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
peptide-based imaging
beta cell imaging
paramagnetic contrast agent
non-invasive imaging
MRI
pancreatic beta cell
Type 1 diabetes
Type 2 diabetes
Online Access:http://www.mdpi.com/1420-3049/23/9/2100

Internet

http://www.mdpi.com/1420-3049/23/9/2100

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