Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics

Abstract Background Curcumin, as a pro-apoptotic agent, is extensively studied to inhibit tumor cell growth of various tumor types. Previous work has demonstrated that curcumin inhibits cancer cell growth by targeting multiple signaling transduction and cellular processes. However, the role of curcu...

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Bibliographic Details
Main Authors: Lihua Wang, Xiwen Chen, Zhuanyun Du, Gefei Li, Mayun Chen, Xi Chen, Guang Liang, Tongke Chen
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ROS
Online Access:http://link.springer.com/article/10.1186/s13046-017-0513-5