Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics
Abstract Background Curcumin, as a pro-apoptotic agent, is extensively studied to inhibit tumor cell growth of various tumor types. Previous work has demonstrated that curcumin inhibits cancer cell growth by targeting multiple signaling transduction and cellular processes. However, the role of curcu...
Main Authors: | Lihua Wang, Xiwen Chen, Zhuanyun Du, Gefei Li, Mayun Chen, Xi Chen, Guang Liang, Tongke Chen |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-03-01
|
Series: | Journal of Experimental & Clinical Cancer Research |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13046-017-0513-5 |
Similar Items
-
Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression
by: Ikuko Nakamae, et al.
Published: (2019-11-01) -
TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis
by: Xutong Sun, et al.
Published: (2020-09-01) -
Neonicotinoid insecticides triggers mitochondrial bioenergetic dysfunction via manipulating ROS-calcium influx pathway in the liver
by: Siwen Li, et al.
Published: (2021-11-01) -
Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4
by: Ismael Obaidi, et al.
Published: (2020-05-01) -
Identification of critical residues in the carboxyl-terminal extension of the mitochondrial DNA polymerase in Saccharomyces cerevisiae
by: Imperial, Robin John Lester
Published: (2011)