Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.

Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to signal through the G protein coupled receptor 81 (GPR81) and to thus modulate inflammatory processes. This study demonstrates that lactate inhibits pro-inflammatory signaling in a GPR81-independent fash...

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Bibliographic Details
Main Authors: Agustina Errea, Delphine Cayet, Philippe Marchetti, Cong Tang, Jerome Kluza, Stefan Offermanns, Jean-Claude Sirard, Martin Rumbo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5112849?pdf=render

Internet

http://europepmc.org/articles/PMC5112849?pdf=render

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