Activation of PPAR gamma receptors reduces levodopa-induced dyskinesias in 6-OHDA-lesioned rats

Activation of PPAR gamma receptors reduces levodopa-induced dyskinesias in 6-OHDA-lesioned rats

Long-term administration of l-3,4-dihydroxyphenylalanine (levodopa), the mainstay treatment for Parkinson's disease (PD), is accompanied by fluctuations in its duration of action and motor complications (dyskinesia) that dramatically affect the quality of life of patients. Levodopa-induced dysk...

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Bibliographic Details
Main Authors: A.A. Martinez, M.G. Morgese, A. Pisanu, T. Macheda, M.A. Paquette, A. Seillier, T. Cassano, A.R. Carta, A. Giuffrida
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Dyskinesia
Parkinson's disease
Cannabinoid
PPARγ
Levodopa
Rosiglitazone
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003702

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http://www.sciencedirect.com/science/article/pii/S0969996114003702

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