Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help

Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help

T cells recognize peptide antigens presented in the context of MHC but can additionally recognize non-conventional ligands. Here the authors show T cells specific for a HIV-1 associated glycopeptide antigen presented by MHC class II help envelope (Env) trimer induced humoral immune responses.

Bibliographic Details
Main Authors: Lina Sun, Amy V. Paschall, Dustin R. Middleton, Mayumi Ishihara, Ahmet Ozdilek, Paeton L. Wantuch, Javid Aceil, Jeremy A. Duke, Celia C. LaBranche, Michael Tiemeyer, Fikri Y. Avci
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16319-0

Internet

https://doi.org/10.1038/s41467-020-16319-0

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