ABCG2 Overexpression Contributes to Pevonedistat Resistance

ABCG2 Overexpression Contributes to Pevonedistat Resistance

MLN4924 (pevonedistat) is a first-in-class NEDD8-activating enzyme (NAE) inhibitor in clinical trials for the treatment of solid tumors and hematologic malignancies. Despite the promising activity of MLN4924 observed in early trials, drug resistance has been noted in some patients. Identifying the u...

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Bibliographic Details
Main Authors: Rishil J. Kathawala, Claudia M. Espitia, Trace M. Jones, Shariful Islam, Pranav Gupta, Yun-Kai Zhang, Zhe-Sheng Chen, Jennifer S. Carew, Steffan T. Nawrocki
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
mln4924
pevonedistat
abcg2
bcrp
drug resistance
Online Access:https://www.mdpi.com/2072-6694/12/2/429

Internet

https://www.mdpi.com/2072-6694/12/2/429

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