Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer

Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer

Abstract Background Developing a universal strategy to improve the specificity and sensitivity of PEGylated nanoaparticles (PEG-NPs) for assisting in the diagnosis of tumors is important in multimodality imaging. Here, we developed the anti-methoxypolyethylene glycol (mPEG) bispecific antibody (BsAb...

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Bibliographic Details
Main Authors: Yi-An Cheng, Tung-Ho Wu, Yun-Ming Wang, Tian-Lu Cheng, I-Ju Chen, Yun-Chi Lu, Kuo-Hsiang Chuang, Chih-Kuang Wang, Chiao-Yun Chen, Rui-An Lin, Huei-Jen Chen, Tzu-Yi Liao, En-Shuo Liu, Fang-Ming Chen
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Nanobiotechnology
Subjects:
Bispecific antibody
PEGylated nanoparticle
Contrast agent
Multimodality image
Polyethylene glycol
Anti-PEG antibody
Online Access:http://link.springer.com/article/10.1186/s12951-020-00680-9

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http://link.springer.com/article/10.1186/s12951-020-00680-9

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