Physiological concentrations of phytosterols enhance the apoptotic effects of 5-fluorouracil in colon cancer cells

Physiological concentrations of phytosterols enhance the apoptotic effects of 5-fluorouracil in colon cancer cells

Combining natural products as co-adjuvants in 5-fluorouracil (5-FU) chemotherapy might enhance the effectiveness of 5-FU by avoiding a high dosage and/or reducing treatment times. We explored the anticancer efficacy of the phytosterols (PS) at concentrations achievable in the human colon, as well as...

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Bibliographic Details
Main Authors: Andrea Álvarez-Sala, María Ángeles Ávila-Gálvez, Antonio Cilla, Reyes Barberá, Guadalupe Garcia-Llatas, Juan Carlos Espín, Antonio González-Sarrías
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Journal of Functional Foods
Subjects:
Phytosterols
Colon cancer cells
5-fluorouracil
Cell cycle
Apoptosis
Drug sensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618304225

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http://www.sciencedirect.com/science/article/pii/S1756464618304225

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