Human Antibodies to VP4 Inhibit Replication of Enteroviruses Across Subgenotypes and Serotypes, and Enhance Host Innate Immunity

Human Antibodies to VP4 Inhibit Replication of Enteroviruses Across Subgenotypes and Serotypes, and Enhance Host Innate Immunity

Hand, foot, and mouth disease (HFMD) is a highly contagious disease that usually affects infants and young children (<5 years). HFMD outbreaks occur frequently in the Asia-Pacific region, and these outbreaks are associated with enormous healthcare and socioeconomic burden. There is currently...

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Bibliographic Details
Main Authors: Siratcha Phanthong, Jaslan Densumite, Watee Seesuay, Jeeraphong Thanongsaksrikul, Salma Teimoori, Nitat Sookrung, Yong Poovorawan, Napa Onvimala, Ratigorn Guntapong, Kovit Pattanapanyasat, Wanpen Chaicumpa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Microbiology
Subjects:
EV71
coxsackieviruses
VP4
human single-chain antibodies
cell penetrating antibody (transbody)
plaque assay
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.562768/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.562768/full

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