The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication

UDP-glucuronosyltransferases (UGTs) form a multigenic family of membrane-bound enzymes expressed in various tissues, including brain. They catalyze the formation of β-Dglucuronides from structurally unrelated substances (drugs, other xenobiotics, as well as endogenous compounds) by the linkage of gl...

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Bibliographic Details
Main Authors: Mohamed eOuzzine, Sandrine eGulberti, Nick eRamalanjaona, Jacques eMagdalou, Sylvie eFournel-Gigleux
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Blood-Brain Barrier
UDP-glucuronosyltransferases
detoxication barrier
drug glucuronidation
glucuronidation of endogenous compounds
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00349/full

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http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00349/full

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