Case Report: Immune and Genomic Characteristics Associated With Hyperprogression in a Patient With Metastatic Deficient Mismatch Repair Gastrointestinal Cancer Treated With Anti-PD-1 Antibody

Case Report: Immune and Genomic Characteristics Associated With Hyperprogression in a Patient With Metastatic Deficient Mismatch Repair Gastrointestinal Cancer Treated With Anti-PD-1 Antibody

Microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR) status of tumors is a distinct predictive biomarker of immune checkpoint inhibitors (ICIs) for colorectal and non-colorectal cancer populations. The overall response rate (ORR) varies from approximately 40% to 60%, indicating tha...

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Bibliographic Details
Main Authors: Wenyue Zhou, Yuwen Zhou, Cheng Yi, Xinyao Shu, Guixia Wei, Xiaorong Chen, Xudong Shen, Meng Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
MSI-H/dMMR
immune checkpoint inhibitors
hyperprogression
gastrointestinal cancer
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.749204/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.749204/full

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