Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

Lipophilic bisphosphonium salts are among the most promising antiprotozoal leads currently under investigation. As part of their preclinical evaluation we here report on their mode of action against African trypanosomes, the etiological agents of sleeping sickness. The bisphosphonium compounds CD38...

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Bibliographic Details
Main Authors: Abdulsalam A.M. Alkhaldi, Jan Martinek, Brian Panicucci, Christophe Dardonville, Alena Zíková, Harry P. de Koning
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320715300233