Modulation of the maladaptive stress response to manage diseases of protein folding.

Modulation of the maladaptive stress response to manage diseases of protein folding.

Diseases of protein folding arise because of the inability of an altered peptide sequence to properly engage protein homeostasis components that direct protein folding and function. To identify global principles of misfolding disease pathology we examined the impact of the local folding environment...

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Bibliographic Details
Main Authors: Daniela Martino Roth, Darren M Hutt, Jiansong Tong, Marion Bouchecareilh, Ning Wang, Theo Seeley, Johanna F Dekkers, Jeffrey M Beekman, Dan Garza, Lawrence Drew, Eliezer Masliah, Richard I Morimoto, William E Balch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4236052?pdf=render

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http://europepmc.org/articles/PMC4236052?pdf=render

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