Abstract OR-8: High-Resolution Structures of Microtubule-Drug Complexes Revealed by Cryo-EM

Background: Microtubules are dynamic protein filaments that are crucial for cell division and constitute key elements of the cytoskeleton. They are assembled from αβ-tubulin heterodimers that form hollow cylindrical structures. There is a large number of naturally occurring compounds that are known...

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Bibliographic Details
Main Authors: Kushal Sejwal, Thorsten B. Blum, Joseph Atherton, Ashwani Sharma, Natacha Olieric, Andrea E. Prota, Carolyn A. Moores, Michel O. Steinmetz
Format: Article
Language:English
Published: International Medical Research and Development Corporation 2019-06-01
Series:International Journal of Biomedicine
Subjects:
Online Access:http://ijbm.org/articles/IJBM_2019_9_S1_OR8.pdf