Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells

Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells

Cutaneous melanoma is often resistant to therapy due to its high plasticity, as well as its ability to metabolise chemotherapeutic drugs. Sphingolipid signalling plays a pivotal role in its progression and metastasis. One of the ways melanoma alters sphingolipid rheostat is via over-expression of ly...

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Bibliographic Details
Main Authors: Michele Lai, Veronica La Rocca, Rachele Amato, Giulia Freer, Mario Costa, Pietro Giorgio Spezia, Paola Quaranta, Giuseppe Lombardo, Daniele Piomelli, Mauro Pistello
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
acid ceramidase
adjuvant therapy
melanoma
autophagy
cancer biology
ceramides
Online Access:https://www.mdpi.com/1422-0067/22/6/3247

Internet

https://www.mdpi.com/1422-0067/22/6/3247

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