Autophagy Induction by HIV-Tat and Methamphetamine in Primary Midbrain Neuronal Cells of Tree Shrews via the mTOR Signaling and ATG5/ATG7 Pathway

Autophagy Induction by HIV-Tat and Methamphetamine in Primary Midbrain Neuronal Cells of Tree Shrews via the mTOR Signaling and ATG5/ATG7 Pathway

Background: Addictive stimulant drugs, such as methamphetamine (METH), increase the risk of exposure to the human immunodeficiency virus-1 (HIV-1) infection and thus predispose individuals to the development of HIV-associated neurocognitive disorders (HANDs). Previous studies have indicated that HIV...

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Bibliographic Details
Main Authors: Juan Li, Wenguang Wang, Pinfen Tong, Chi-Kwan Leung, Genmeng Yang, Zhen Li, Na Li, Xiaomei Sun, Yuanyuan Han, Caixia Lu, Dexuan Kuang, Jiejie Dai, Xiaofeng Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neuroscience
Subjects:
HIV-Tat
METH
autophagy
dopaminergic neuronal cells
tree shrew
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00921/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00921/full

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