Increasing pro-survival factors within whole brain tissue of Sprague Dawley rats via intracerebral administration of modified valproic acid

Increasing pro-survival factors within whole brain tissue of Sprague Dawley rats via intracerebral administration of modified valproic acid

Neural tissue exposure to valproic acid (VPA) increases several pro-survival phospho-proteins that can be used as biomarkers for indicating a beneficial drug response (pAktSer473, pGSK3βSer9, pErk1/2Thr202/Tyr204). Unfortunately, targeting VPA to neural tissue is a problem due to severe asymmetrical...

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Bibliographic Details
Main Authors: Ryan C. Bates, Bradley J. Stith, Karen E. Stevens
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Journal of Pharmacological Sciences
Subjects:
Intracerebral administration
Phospho-proteins
Pro-survival
Brain injury
Valproic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315001231

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http://www.sciencedirect.com/science/article/pii/S1347861315001231

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