Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA

Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA

Efficient protocols based on Cu(I)-catalyzed azide–alkyne cycloaddition were developed for the synthesis of conjugates of pyrrole–imidazole polyamide minor groove binders (MGB) with fluorophores and with triplex-forming oligonucleotides (TFOs). Diverse bifunctional linkers were synthesized and used...

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Bibliographic Details
Main Authors: Svetlana V. Vasilyeva, Vyacheslav V. Filichev, Alexandre S. Boutorine
Format: Article
Language:English
Published: Beilstein-Institut 2016-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
binding affinity
click chemistry
Cu(I)-catalyzed azide–alkyne cycloaddition
pyrrole–imidazole polyamides
sequence specificity: DNA
triplex-forming oligonucleotides
Online Access:https://doi.org/10.3762/bjoc.12.128

Internet

https://doi.org/10.3762/bjoc.12.128

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