Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer

Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer

Castration-resistant prostate cancer remains as an incurable disease. Exploiting DNA damage repair defects via inhibition of poly (ADP-ribose) polymerase (PARP) is becoming an attractive therapeutic option. The TOPARP-A clinical trial demonstrated that the PARP inhibitor olaparib may be an effective...

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Bibliographic Details
Main Authors: Alan P Lombard, Chengfei Liu, Cameron M Armstrong, Leandro S D'Abronzo, Wei Lou, Hongwu Chen, Marc Dall'Era, Paramita M Ghosh, Christopher P Evans, Allen C Gao
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523319301615

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http://www.sciencedirect.com/science/article/pii/S1936523319301615

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