Suppression of HIV replication by CD8+regulatory T-cells in elite controllers

Suppression of HIV replication by CD8+regulatory T-cells in elite controllers

We previously demonstrated in the Chinese macaque model that an oral vaccine made of inactivated SIV and lactobacillus plantarum induced CD8+regulatory T-cells which suppressed the activation of SIV+CD4+T-cells, prevented SIV replication and protected macaques from SIV challenges.Here ,we s...

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Bibliographic Details
Main Authors: Wei eLu, Chen eSong, Chunhui eLai, Jun eKang, Hua eFang, Hong eDao, Mingyue eLai, Jianhua eFan, Weizhong eGuo, Linchun eFu, Jean Marie eAndrieu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Immunology
Subjects:
HIV replication
Key-words: elite controllers
suppressive/tolerogenic CD8+T-cells
CD8+ regulatory T-cells
HLA-B:Bw4-80Ile-expressing CD4+T-cells
KIR3DL1-expressing CD8+T-cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00134/full

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http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00134/full

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