Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome

Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome

Williams Syndrome (WS, [MIM 194050]) is a disorder caused by a hemizygous deletion of 25–30 genes on chromosome 7q11.23. Several of these genes including those encoding cytoplasmic linker protein-115 (CYLN2) and general transcription factors (GTF2I and GTF2IRD1) are expressed in the brain and may co...

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Bibliographic Details
Main Authors: J.M. van Hagen, J.N. van der Geest, R.S. van der Giessen, G.C. Lagers-van Haselen, H.J.F.M.M. Eussen, J.J.P. Gille, L.C.P. Govaerts, C.H. Wouters, I.F.M. de Coo, C.C. Hoogenraad, S.K.E. Koekkoek, M.A. Frens, N. van Camp, A. van der Linden, M.C.E. Jansweijer, S.S. Thorgeirsson, C.I. De Zeeuw
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Neurobiology of Disease
Subjects:
Human
Mice
Motor behavior
Cognition
Genetic disorder
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106003159

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http://www.sciencedirect.com/science/article/pii/S0969996106003159

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