Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1

Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1

Indoxyl sulfate (IS) is an accumulative protein-bound uremic toxin found in patients with kidney disease. It is reported that IS impairs the vascular endothelium, but a comprehensive overview of all mechanisms active in IS-injury currently remains lacking. Here we performed RNA sequencing in human u...

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Bibliographic Details
Main Authors: Jiayi Pei, Rio Juni, Magdalena Harakalova, Dirk J. Duncker, Folkert W. Asselbergs, Pieter Koolwijk, Victor van Hinsbergh, Marianne C. Verhaar, Michal Mokry, Caroline Cheng
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Toxins
Subjects:
indoxyl sulfate
chronic kidney disease
reactive oxygen species
CYP1B1
angiogenesis
Online Access:https://www.mdpi.com/2072-6651/11/8/454

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https://www.mdpi.com/2072-6651/11/8/454

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