Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells

Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells

Abstract Background Chronic myeloid leukemia (CML) is a BCR-ABL1 + myeloproliferative neoplasm marked by increased myeloproliferation and presence of leukemic cells resistant to apoptosis. The current first-line therapy for CML is administration of the tyrosine kinase inhibitors imatinib mesylate, d...

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Bibliographic Details
Main Authors: Rogério Bodini Benati, Tássia Rafaela Costa, Maira da Costa Cacemiro, Suely Vilela Sampaio, Fabíola Attié de Castro, Sandra Mara Burin
Format: Article
Language:English
Published: SciELO 2018-12-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Chronic myeloid leukemia
Bcr-Abl
Phospholipase A2
MjTX-I
Bothrops moojeni
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s40409-018-0180-9

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http://link.springer.com/article/10.1186/s40409-018-0180-9

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