Phosphokinome Analysis of Barth Syndrome Lymphoblasts Identify Novel Targets in the Pathophysiology of the Disease

Phosphokinome Analysis of Barth Syndrome Lymphoblasts Identify Novel Targets in the Pathophysiology of the Disease

Barth Syndrome (BTHS) is a rare X-linked genetic disease in which the specific biochemical deficit is a reduction in the mitochondrial phospholipid cardiolipin (CL) as a result of a mutation in the CL transacylase tafazzin. We compared the phosphokinome profile in Epstein-Barr-virus-transformed lymp...

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Bibliographic Details
Main Authors: Prasoon Agarwal, Laura K. Cole, Abin Chandrakumar, Kristin D. Hauff, Amir Ravandi, Vernon W. Dolinsky, Grant M. Hatch
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
cardiolipin
Barth Syndrome
phosphokinome
phosphoproteins
rare genetic disease
phospholipid
human lymphoblasts
mitochondria
cardiomyopathy
neutropenia
Online Access:http://www.mdpi.com/1422-0067/19/7/2026

Internet

http://www.mdpi.com/1422-0067/19/7/2026

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