Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats

Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats

Background: Microglia are key mediators of inflammation during perinatal brain injury. As shown experimentally after inflammation-sensitized hypoxic ischemic (HI) brain injury, microglia are activated into a pro-inflammatory status 24 h after HI involving the NLRP3 inflammasome pathway. The chemokin...

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Bibliographic Details
Main Authors: Meray Serdar, Karina Kempe, Ralf Herrmann, Daniel Picard, Marc Remke, Josephine Herz, Ivo Bendix, Ursula Felderhoff-Müser, Hemmen Sabir
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neurology
Subjects:
newborn
HIE
brain
infection
inflammation
microglia
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.540878/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2020.540878/full

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