Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry

Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry

Inspired by the many reported successful applications of DNA-encoded chemical libraries in drug discovery projects with protein targets, we decided to apply this platform to nucleic acid targets. We used a 120-billion-compound set of 33 distinct DNA-encoded chemical libraries and affinity-mediated s...

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Bibliographic Details
Main Authors: Alexander Litovchick, Xia Tian, Michael I. Monteiro, Kaitlyn M. Kennedy, Marie-Aude Guié, Paolo Centrella, Ying Zhang, Matthew A. Clark, Anthony D. Keefe
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
DNA-encoded chemical library
affinity-mediated selection
G-quartet
c-myc
SPR
Online Access:https://www.mdpi.com/1420-3049/24/10/2026

Internet

https://www.mdpi.com/1420-3049/24/10/2026

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