Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry
Inspired by the many reported successful applications of DNA-encoded chemical libraries in drug discovery projects with protein targets, we decided to apply this platform to nucleic acid targets. We used a 120-billion-compound set of 33 distinct DNA-encoded chemical libraries and affinity-mediated s...
Main Authors: | Alexander Litovchick, Xia Tian, Michael I. Monteiro, Kaitlyn M. Kennedy, Marie-Aude Guié, Paolo Centrella, Ying Zhang, Matthew A. Clark, Anthony D. Keefe |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-05-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/24/10/2026 |
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