The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

Abstract There is a great clinical need to identify the underlying mechanisms, as well as related biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a central pathophysiological feature of TBI. NLRP3 inflammasome activity is a necessary component of the innate...

Full description

Bibliographic Details
Main Authors: William T. O’Brien, Louise Pham, Georgia F. Symons, Mastura Monif, Sandy R. Shultz, Stuart J. McDonald
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
TBI
Concussion
Mild traumatic brain injury
Chronic traumatic encephalopathy
Microglia
Online Access:http://link.springer.com/article/10.1186/s12974-020-01778-5

Internet

http://link.springer.com/article/10.1186/s12974-020-01778-5

Similar Items