Generation of a Retinoblastoma (Rb)1-inducible dominant negative (DN) mouse model

Generation of a Retinoblastoma (Rb)1-inducible dominant negative (DN) mouse model

Retinoblastoma 1 (Rb1) is an essential gene regulating cellular proliferation, differentiation, and homeostasis. To exert these functions, Rb1 is recruited and physically interacts with a growing variety of signaling pathways. While Rb1 does not appear to be ubiquitously expressed, its expression ha...

Full description

Bibliographic Details
Main Authors: Shikha eTarang, Songila MSR Doi, Channabasavaiah B Gurumurthy, Donald W Harms, Rolen eQuadros, Sonia M. Rocha-Sanchez
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Doxycycline
Regeneration
Retinoblastoma
Inner ear
Hair cell
dominant-negative
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00052/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00052/full

Similar Items