Repositioning Lopinavir, an HIV Protease Inhibitor, as a Promising Antifungal Drug: Lessons Learned from <i>Candida albicans</i>—In Silico, In Vitro and In Vivo Approaches

Repositioning Lopinavir, an HIV Protease Inhibitor, as a Promising Antifungal Drug: Lessons Learned from <i>Candida albicans</i>—In Silico, In Vitro and In Vivo Approaches

The repurposing strategy was applied herein to evaluate the effects of lopinavir, an aspartic protease inhibitor currently used in the treatment of HIV-infected individuals, on the globally widespread opportunistic human fungal pathogen <i>Candida albicans</i> by using in silico, in vitr...

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Bibliographic Details
Main Authors: André L. S. Santos, Lys A. Braga-Silva, Diego S. Gonçalves, Lívia S. Ramos, Simone S. C. Oliveira, Lucieri O. P. Souza, Vanessa S. Oliveira, Roberto D. Lins, Marcia R. Pinto, Julian E. Muñoz, Carlos P. Taborda, Marta H. Branquinha
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Journal of Fungi
Subjects:
<i>Candida albicans</i>
drug repurposing
HIV protease inhibitors
secreted aspartic proteases
lopinavir
virulence
Online Access:https://www.mdpi.com/2309-608X/7/6/424

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https://www.mdpi.com/2309-608X/7/6/424

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